Anthony Palumbo was born in Michigan in 1980. He grew up in Pennsylvania in an artistic household and studied painting at Philadelphia's Pennsylvania Academy of the Fine Arts.
He works as an illustrator and gallery artist. He has shown in galleries in Philadelphia and New York. His paintings are in the collections of private individuals and prominent institutions including the Pennsylvania Academy of the Fine Arts. As an illustrator his art has appeared on book covers, in collectible card games, and in video games. His clients include Night Shade Books, Wizards of the Coast, Fantasy Flight Games, and Heavy Metal Magazine.
He lives and works in Philadelphia.